# Introduction

Use [this workflow](https://atomic-lab.gitbook.io/pandora/example-workflows/example-2-sars-cov-2-infection/covid-pitch-workflow) to explore the durability of humoral and cellular immune responses longitudinally after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The dataset consists of 86 UK health workers who presented with symptomatic or asymptomatic infection prior to vaccination. Samples were collected from the participants over a period of 6 months. 

The **main objectives** are to:

1. **Visualize the trajectories of diverse immune responses over 6 months** after infection by analyzing how trajectories differ based on initial disease severity and the correlations between different immune parameters
2. **Predict pre-defined long-term antibody responder status based on early immune signatures**

The dataset can be downloaded from this [**Zenodo data repository**](https://zenodo.org/records/4905965) or from below: 

{% file src="<https://1845146574-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FZMrkCA3Bqd62Gp0kAk79%2Fuploads%2FcSTu7kRcodot3a7SMRxx%2Fcovid_pitch.csv?alt=media&token=27380f56-7cc5-43b8-9973-380a95cee4d0>" %}

For more details, refer to the publication that describes the cohort and various analyses performed on the dataset:

[**Divergent trajectories of antiviral memory after SARS-CoV-2 infection**](https://doi.org/10.1038/s41467-022-28898-1)

(*Tomic, A., Skelly, D.T., Ogbe, A. et al. Nat Commun 13, 1251 (2022)*)

<figure><img src="https://1845146574-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FZMrkCA3Bqd62Gp0kAk79%2Fuploads%2FG7Msq27HKpRnFw1jy5v2%2Fimage.png?alt=media&#x26;token=6550901c-546a-4640-9671-1f48f8cf18ab" alt=""><figcaption><p>Figure 1. Clinical study overview</p></figcaption></figure>