Introduction

SARS-CoV-2 infection example workflow

Use this workflow to explore the durability of humoral and cellular immune responses longitudinally after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The dataset consists of 86 UK health workers who presented with symptomatic or asymptomatic infection prior to vaccination. Samples were collected from the participants over a period of 6 months.

The main objectives are to:

1. Visualize the trajectories of diverse immune responses over 6 months after infection by analyzing how trajectories differ based on initial disease severity and the correlations between different immune parameters

2. Predict pre-defined long-term antibody responder status based on early immune signatures

The dataset can be downloaded from this Zenodo data repository or from below:

114KB

covid_pitch.csv

For more details, refer to the publication that describes the cohort and various analyses performed on the dataset:

Divergent trajectories of antiviral memory after SARS-CoV-2 infection

(Tomic, A., Skelly, D.T., Ogbe, A. et al. Nat Commun 13, 1251 (2022))

Figure 1. Clinical study overview